@article{90891,
  keywords = {Base Sequence, Humans, Molecular Sequence Data, Genetic Complementation Test, Conserved Sequence, Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, Evolution, Molecular, Gene Silencing, Epigenesis, Genetic, DNA Damage, Genomic Instability, DNA Helicases, Telomere Homeostasis, G-Quadruplexes, Mutation Rate},
  author = {Katrin Paeschke and Matthew Bochman and Daniela Garcia and Petr Cejka and Katherine Friedman and Stephen Kowalczykowski and Virginia Zakian},
  title = {Pif1 family helicases suppress genome instability at G-quadruplex motifs.},
  abstract = { The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Moreover, Pif1 helicases from organisms separated by more than 3 billion years of evolution suppressed DNA damage at G-quadruplex motifs in yeast. The G-quadruplex-induced damage generated in the absence of Pif1 helicases led to new genetic and epigenetic changes. Furthermore, when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening. },
  year = {2013},
  journal = {Nature},
  volume = {497},
  pages = {458-62},
  month = {05/2013},
  issn = {1476-4687},
  doi = {10.1038/nature12149},
  language = {eng},
}