@article{91091,
  keywords = {Nucleic Acid Conformation, RNA, cell cycle, Protein Binding, DNA-Binding Proteins, Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, S Phase, Telomere, RNA, Fungal, Telomerase, Telomere-Binding Proteins, Antigens, Nuclear, Ku Autoantigen},
  author = {Timothy Fisher and Andrew Taggart and Virginia Zakian},
  title = {Cell cycle-dependent regulation of yeast telomerase by Ku.},
  abstract = { The heterodimeric Ku complex affects telomere structure in diverse organisms. We report here that in the absence of Ku, the catalytic subunit of telomerase, Est2p, was not telomere-associated in G1 phase, and its association in late S phase was decreased. The telomere association of Est1p, a telomerase component that binds telomeres only in late S phase, was also reduced in the absence of Ku. The effects of Ku on telomerase binding require a 48-nucleotide (nt) stem-loop region of TLC1 telomerase RNA. Ku interacts with TLC1 RNA via this 48-nt region throughout the cell cycle, but this interaction was reduced after telomere replication. These data support a model in which Ku recruits telomerase to telomeres in G1 phase when telomerase is inactive and promotes telomerase-mediated telomere lengthening in late S phase. },
  year = {2004},
  journal = {Nat Struct Mol Biol},
  volume = {11},
  pages = {1198-205},
  month = {12/2004},
  issn = {1545-9993},
  doi = {10.1038/nsmb854},
  language = {eng},
}