@article{91136,
  keywords = {cell cycle, Models, Biological, Enzyme Activation, DNA-Binding Proteins, Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, Genes, Fungal, Alleles, S Phase, Polymerase Chain Reaction, Telomere, G1 Phase, Precipitin Tests, RNA, Fungal, Telomerase, Telomere-Binding Proteins, DNA, Fungal},
  author = {Andrew Taggart and Shu-Chun Teng and Virginia Zakian},
  title = {Est1p as a cell cycle-regulated activator of telomere-bound telomerase.},
  abstract = { In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and Est3p are thought to form a complex that acts late during chromosome replication (S phase) upon recruitment by Cdc13p, a telomeric DNA binding protein. Consistent with this model, we show that Est1p, Est2p, and Cdc13p are telomere-associated at this time. However, Est2p, but not Est1p, also binds telomeres before late S phase. The cdc13-2 allele has been proposed to be defective in recruitment, yet Est1p and Est2p telomere association persists in cdc13-2 cells. These findings suggest a model in which Est1p binds telomeres late in S phase and interacts with Cdc13p to convert inactive, telomere-bound Est2p to an active form. },
  year = {2002},
  journal = {Science},
  volume = {297},
  pages = {1023-6},
  month = {08/2002},
  issn = {1095-9203},
  doi = {10.1126/science.1074968},
  language = {eng},
}