@article{91146,
  keywords = {DNA, Catalysis, Chromosomes, cell cycle, Time Factors, Models, Genetic, Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, DNA Replication, Alleles, Telomere, Adenosine Triphosphatases, DNA Helicases},
  author = {Andreas Ivessa and Jin-Qiu Zhou and Vince Schulz and Ellen Monson and Virginia Zakian},
  title = {Saccharomyces Rrm3p, a 5{\textquoteright} to 3{\textquoteright} DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.},
  abstract = { In wild-type Saccharomyces cerevisiae, replication forks slowed during their passage through telomeric C(1-3)A/TG(1-3) tracts. This slowing was greatly exacerbated in the absence of RRM3, shown here to encode a 5{\textquoteright} to 3{\textquoteright} DNA helicase. Rrm3p-dependent fork progression was seen at a modified Chromosome VII-L telomere, at the natural X-bearing Chromosome III-L telomere, and at Y{\textquoteright}-bearing telomeres. Loss of Rrm3p also resulted in replication fork pausing at specific sites in subtelomeric DNA, such as at inactive replication origins, and at internal tracts of C(1-3)A/TG(1-3) DNA. The ATPase/helicase activity of Rrm3p was required for its role in telomeric and subtelomeric DNA replication. Because Rrm3p was telomere-associated in vivo, it likely has a direct role in telomere replication. },
  year = {2002},
  journal = {Genes Dev},
  volume = {16},
  pages = {1383-96},
  month = {06/2002},
  issn = {0890-9369},
  doi = {10.1101/gad.982902},
  language = {eng},
}