@article{91171,
  keywords = {Humans, Immunohistochemistry, cell cycle, Transcription, Genetic, Trans-Activators, Recombinant Fusion Proteins, Genes, Reporter, DNA-Binding Proteins, Cell Nucleus, Saccharomyces cerevisiae Proteins, Fungal Proteins, Saccharomyces, Gene Expression Regulation, Fungal, Gene Silencing, Telomere, Silent Information Regulator Proteins, Saccharomyces cerevisiae},
  author = {Tham and Wyithe and Ko Ferrigno and Silver and Zakian},
  title = {Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions.},
  abstract = { The left telomere of Saccharomyces chromosome VII was often localized near the nuclear periphery, even in cells lacking the silencing proteins Sir3 or Hdf1. This association was lost in late mitotic cells and when transcription was induced through the telomeric tract. Although in silencing competent cells there was no correlation between the fraction of cells in which a telomeric gene was repressed and the fraction of cells in which it was localized to the periphery, no condition was found where the telomere was both silenced and away from the periphery. We conclude that localization of a telomere to the nuclear periphery is not sufficient for transcriptional repression nor does it affect the stability function of yeast telomeres. },
  year = {2001},
  journal = {Mol Cell},
  volume = {8},
  pages = {189-99},
  month = {07/2001},
  issn = {1097-2765},
  language = {eng},
}