@article{91266,
  keywords = {Base Sequence, Cations, Magnesium, cell cycle, Molecular Sequence Data, Hot Temperature, Saccharomyces cerevisiae, DNA Replication, Repetitive Sequences, Nucleic Acid, Plasmids, Telomere, RNA, Fungal, Telomerase, DNA, Fungal},
  author = {Wellinger and Ethier and Labrecque and Zakian},
  title = {Evidence for a new step in telomere maintenance.},
  abstract = { The strand of telomeric DNA that runs 5{\textquoteright}-3{\textquoteright} toward a chromosome end is typically G rich. Telomerase-generated G tails are expected at one end of individual DNA molecules. Saccharomyces telomeres acquire TG1-3 tails late in S phase. Moreover, the telomeres of linear plasmids can interact when the TG1-3 tails are present. Molecules that mimic the structures predicted for telomere replication intermediates were generated in vitro. These in vitro generated molecules formed telomere-telomere interactions similar to those on molecules isolated from yeast, but only if both ends that interacted had a TG1-3 tail. Moreover, TG1-3 tails were generated in vivo in cells lacking telomerase. These data suggest a new step in telomere maintenance, cell cycle-regulated degradation of the C1-3A strand, which can generate a potential substrate for telomerase and telomere-binding proteins at every telomere. },
  year = {1996},
  journal = {Cell},
  volume = {85},
  pages = {423-33},
  month = {05/1996},
  issn = {0092-8674},
  language = {eng},
}