@article{91316,
  keywords = {Transcription, Genetic, Trans-Activators, Regulatory Sequences, Nucleic Acid, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Repetitive Sequences, Nucleic Acid, Telomere, DNA, Fungal, Orotidine-5{\textquoteright}-Phosphate Decarboxylase},
  author = {Stavenhagen and Zakian},
  title = {Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae.},
  abstract = { Telomeric position effect (TPE) refers to the ability of telomeres to repress the transcription of genes in their vicinity. Internal stretches of C1-3A DNA, the sequence found at Saccharomyces telomeres, also repressed transcription of nearby genes. This repression, hereafter called C1-3A-based silencing, was observed at several chromosomal loci, including on a circular chromosome. The magnitude of C1-3A-based silencing was increased by both proximity to a telomere and increased length of the C1-3A tracts. C1-3A-based silencing was affected by many of the same genes and conditions that influence TPE and acted in an orientation-independent manner. Thus, in yeast, an expanded array of a simple repetitive DNA, C1-3A, is sufficient to promote the assembly of a transcriptionally silent chromosomal domain. },
  year = {1994},
  journal = {Genes Dev},
  volume = {8},
  pages = {1411-22},
  month = {06/1994},
  issn = {0890-9369},
  language = {eng},
}