@article{91401,
  keywords = {Mutation, Phenotype, Diploidy, Genotype, Cell Division, Saccharomyces cerevisiae, Genes, Fungal, Plasmids, Alleles, Crosses, Genetic, Transformation, Genetic, Blotting, Southern, DNA, Fungal},
  author = {Sweeney and Zakian},
  title = {Extrachromosomal elements cause a reduced division potential in nib 1 strains of Saccharomyces cerevisiae.},
  abstract = { The nib 1 allele of yeast confers a sensitivity to an endogenous plasmid, 2 mu DNA, in that nib 1 strains bearing 2 mu DNA (cir+) exhibit a reduction in division potential. In the present study, the reduction in division potential characteristic of nib 1 cir+ strains is shown to be dependent on the simultaneous presence of both the A and the D open reading frames of 2 mu DNA as well as on the presence of an unidentified extrachromosomal element other than 2 mu DNA. Furthermore, in nib 1 strains, an uncharacterized extrachromosomal element can cause a less severe reduction of division potential in the absence of intact 2 mu DNA. Thus, the nib 1 allele may confer a generalized sensitivity to extrachromosomal elements. },
  year = {1989},
  journal = {Genetics},
  volume = {122},
  pages = {749-57},
  month = {08/1989},
  issn = {0016-6731},
  language = {eng},
}