Virginia Zakian

First name

Virginia

Last name

Zakian

Vega, Leticia, Maria Mateyak, and Virginia Zakian. (2003) 2003. “Getting to the End: Telomerase Access in Yeast and Humans.”. Nat Rev Mol Cell Biol 4 (12): 948-59. doi:10.1038/nrm1256.

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Callahan, Julie, Kenneth Andrews, Virginia Zakian, and Catherine Freudenreich. (2003) 2003. “Mutations in Yeast Replication Proteins That Increase CAG CTG Expansions Also Increase Repeat Fragility.”. Mol Cell Biol 23 (21): 7849-60.

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Taggart, Andrew, and Virginia Zakian. (2003) 2003. “Telomerase: What Are the Est Proteins Doing?”. Curr Opin Cell Biol 15 (3): 275-80.

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Alexander, Mary Kate, and Virginia Zakian. (2003) 2003. “Rap1p Telomere Association Is Not Required for Mitotic Stability of a C(3)TA(2) Telomere in Yeast.”. EMBO J 22 (7): 1688-96. doi:10.1093/emboj/cdg154.

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Ivessa, Andreas, and Virginia Zakian. (2002) 2002. “To Fire or Not to Fire: Origin Activation in Saccharomyces Cerevisiae Ribosomal DNA.”. Genes Dev 16 (19): 2459-64. doi:10.1101/gad.1033702.

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Taggart, Andrew, Shu-Chun Teng, and Virginia Zakian. (2002) 2002. “Est1p As a Cell Cycle-Regulated Activator of Telomere-Bound Telomerase.”. Science 297 (5583): 1023-6. doi:10.1126/science.1074968.

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Zhou, Jin-Qiu, Haiyan Qi, Vincent Schulz, Maria Mateyak, Ellen Monson, and Virginia Zakian. (2002) 2002. “Schizosaccharomyces Pombe pfh1+ Encodes an Essential 5’ to 3’ DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases.”. Mol Biol Cell 13 (6): 2180-91.

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Ivessa, Andreas, Jin-Qiu Zhou, Vince Schulz, Ellen Monson, and Virginia Zakian. (2002) 2002. “Saccharomyces Rrm3p, a 5’ to 3’ DNA Helicase That Promotes Replication Fork Progression through Telomeric and Subtelomeric DNA.”. Genes Dev 16 (11): 1383-96. doi:10.1101/gad.982902.

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Tham, Wai-Hong, and Virginia Zakian. (2002) 2002. “Transcriptional Silencing at Saccharomyces Telomeres: Implications for Other Organisms.”. Oncogene 21 (4): 512-21. doi:10.1038/sj.onc.1205078.

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Bessler, Jessica, and Virginia Zakian. (2004) 2004. “The Amino Terminus of the Saccharomyces Cerevisiae DNA Helicase Rrm3p Modulates Protein Function Altering Replication and Checkpoint Activity.”. Genetics 168 (3): 1205-18. doi:10.1534/genetics.104.028035.

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Fisher, Timothy, Andrew Taggart, and Virginia Zakian. (2004) 2004. “Cell Cycle-Dependent Regulation of Yeast Telomerase by Ku.”. Nat Struct Mol Biol 11 (12): 1198-205. doi:10.1038/nsmb854.

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Torres, Jorge, Sandra Schnakenberg, and Virginia Zakian. (2004) 2004. “Saccharomyces Cerevisiae Rrm3p DNA Helicase Promotes Genome Integrity by Preventing Replication Fork Stalling: Viability of Rrm3 Cells Requires the Intra-S-Phase Checkpoint and Fork Restart Activities.”. Mol Cell Biol 24 (8): 3198-212.

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Torres, Jorge, Jessica Bessler, and Virginia Zakian. (2004) 2004. “Local Chromatin Structure at the Ribosomal DNA Causes Replication Fork Pausing and Genome Instability in the Absence of the S. Cerevisiae DNA Helicase Rrm3p.”. Genes Dev 18 (5): 498-503. doi:10.1101/gad.1154704.

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Ivessa, Andreas, Brian Lenzmeier, Jessica Bessler, Lara Goudsouzian, Sandra Schnakenberg, and Virginia Zakian. (2003) 2003. “The Saccharomyces Cerevisiae Helicase Rrm3p Facilitates Replication past Nonhistone Protein-DNA Complexes.”. Mol Cell 12 (6): 1525-36.

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Azvolinsky, Anna, Stephen Dunaway, Jorge Torres, Jessica Bessler, and Virginia Zakian. (2006) 2006. “The S. Cerevisiae Rrm3p DNA Helicase Moves With the Replication Fork and Affects Replication of All Yeast Chromosomes.”. Genes Dev 20 (22): 3104-16. doi:10.1101/gad.1478906.

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Boulé, Jean-Baptiste, and Virginia Zakian. 2006. “Roles of Pif1-Like Helicases in the Maintenance of Genomic Stability.”. Nucleic Acids Res 34 (15): 4147-53. doi:10.1093/nar/gkl561.

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Boulé, Jean-Baptiste, Leticia Vega, and Virginia Zakian. (2005) 2005. “The Yeast Pif1p Helicase Removes Telomerase from Telomeric DNA.”. Nature 438 (7064): 57-61. doi:10.1038/nature04091.

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Fisher, Timothy, and Virginia Zakian. (2005) 2005. “Ku: A Multifunctional Protein Involved in Telomere Maintenance.”. DNA Repair (Amst) 4 (11): 1215-26. doi:10.1016/j.dnarep.2005.04.021.

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Muller, Carol, Sally Ride, Janie Fouke, Telle Whitney, Denice Denton, Nancy Cantor, Donna Nelson, et al. (2005) 2005. “Gender Differences and Performance in Science.”. Science 307 (5712): 1043. doi:10.1126/science.307.5712.1043b.

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Sabourin, Michelle, and Virginia Zakian. (2008) 2008. “ATM-Like Kinases and Regulation of Telomerase: Lessons from Yeast and Mammals.”. Trends Cell Biol 18 (7): 337-46. doi:10.1016/j.tcb.2008.04.004.

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Webb, Christopher, and Virginia Zakian. (2008) 2008. “Identification and Characterization of the Schizosaccharomyces Pombe TER1 Telomerase RNA.”. Nat Struct Mol Biol 15 (1): 34-42. doi:10.1038/nsmb1354.

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Mondoux, Michelle, and Virginia Zakian. (2007) 2007. “Subtelomeric Elements Influence But Do Not Determine Silencing Levels at Saccharomyces Cerevisiae Telomeres.”. Genetics 177 (4): 2541-6. doi:10.1534/genetics.107.079806.

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Mondoux, Michelle, Jillian Scaife, and Virginia Zakian. (2007) 2007. “Differential Nuclear Localization Does Not Determine the Silencing Status of Saccharomyces Cerevisiae Telomeres.”. Genetics 177 (4): 2019-29. doi:10.1534/genetics.107.079848.

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Boulé, Jean-Baptiste, and Virginia Zakian. 2007. “The Yeast Pif1p DNA Helicase Preferentially Unwinds RNA DNA Substrates.”. Nucleic Acids Res 35 (17): 5809-18. doi:10.1093/nar/gkm613.

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Sabourin, Michelle, Creighton Tuzon, and Virginia Zakian. (2007) 2007. “Telomerase and Tel1p Preferentially Associate With Short Telomeres in S. Cerevisiae.”. Mol Cell 27 (4): 550-61. doi:10.1016/j.molcel.2007.07.016.

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Vega, Leticia, Jane Phillips, Brian Thornton, Jennifer Benanti, Mutiat Onigbanjo, David Toczyski, and Virginia Zakian. (2007) 2007. “Sensitivity of Yeast Strains With Long G-Tails to Levels of Telomere-Bound Telomerase.”. PLoS Genet 3 (6): e105. doi:10.1371/journal.pgen.0030105.

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Sabourin, Michelle, Creighton Tuzon, Timothy Fisher, and Virginia Zakian. (2007) 2007. “A Flexible Protein Linker Improves the Function of Epitope-Tagged Proteins in Saccharomyces Cerevisiae.”. Yeast 24 (1): 39-45. doi:10.1002/yea.1431.

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Goudsouzian, Lara, Creighton Tuzon, and Virginia Zakian. (2006) 2006. “S. Cerevisiae Tel1p and Mre11p Are Required for Normal Levels of Est1p and Est2p Telomere Association.”. Mol Cell 24 (4): 603-10. doi:10.1016/j.molcel.2006.10.005.

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Mateyak, Maria, and Virginia Zakian. (2006) 2006. “Human PIF Helicase Is Cell Cycle Regulated and Associates With Telomerase.”. Cell Cycle 5 (23): 2796-804. doi:10.4161/cc.5.23.3524.

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Pinter, Stefan, Sarah Aubert, and Virginia Zakian. (2008) 2008. “The Schizosaccharomyces Pombe Pfh1p DNA Helicase Is Essential for the Maintenance of Nuclear and Mitochondrial DNA.”. Mol Cell Biol 28 (21): 6594-608. doi:10.1128/MCB.00191-08.

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Capra, John, Katrin Paeschke, Mona Singh, and Virginia Zakian. (2010) 2010. “G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated With Distinct Genomic Features in Saccharomyces Cerevisiae.”. PLoS Comput Biol 6 (7): e1000861. doi:10.1371/journal.pcbi.1000861.

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Paeschke, Katrin, Karin McDonald, and Virginia Zakian. (2010) 2010. “Telomeres: Structures in Need of Unwinding.”. FEBS Lett 584 (17): 3760-72. doi:10.1016/j.febslet.2010.07.007.

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Boulé, Jean-Baptiste, and Virginia Zakian. 2010. “Characterization of the Helicase Activity and Anti-Telomerase Properties of Yeast Pif1p in Vitro.”. Methods Mol Biol 587: 359-76. doi:10.1007/978-1-60327-355-8_25.

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Bochman, Matthew, Nasim Sabouri, and Virginia Zakian. (2010) 2010. “Unwinding the Functions of the Pif1 Family Helicases.”. DNA Repair (Amst) 9 (3): 237-49. doi:10.1016/j.dnarep.2010.01.008.

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Zakian, Virginia. (2009) 2009. “The Ends Have Arrived.”. Cell 139 (6): 1038-40. doi:10.1016/j.cell.2009.11.033.

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Wu, Yun, and Virginia Zakian. (2010) 2010. “Identity Crisis When Telomeres Left Unprotected.”. J Mol Cell Biol 2 (1): 14-6. doi:10.1093/jmcb/mjp031.

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Azvolinsky, Anna, Paul Giresi, Jason Lieb, and Virginia Zakian. (2009) 2009. “Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces Cerevisiae.”. Mol Cell 34 (6): 722-34. doi:10.1016/j.molcel.2009.05.022.

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Ribeyre, Cyril, Judith Lopes, Jean-Baptiste Boulé, Aurèle Piazza, Aurore Guédin, Virginia Zakian, Jean-Louis Mergny, and Alain Nicolas. (2009) 2009. “The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences in Vivo.”. PLoS Genet 5 (5): e1000475. doi:10.1371/journal.pgen.1000475.

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Chan, Angela, Jean-Baptiste Boulé, and Virginia Zakian. (2008) 2008. “Two Pathways Recruit Telomerase to Saccharomyces Cerevisiae Telomeres.”. PLoS Genet 4 (10): e1000236. doi:10.1371/journal.pgen.1000236.

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Webb, Christopher, and Virginia Zakian. (2012) 2012. “Schizosaccharomyces Pombe Ccq1 and TER1 Bind the 14-3-3-Like Domain of Est1, Which Promotes and Stabilizes Telomerase-Telomere Association.”. Genes Dev 26 (1): 82-91. doi:10.1101/gad.181826.111.

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Wu, Yun, and Virginia Zakian. (2011) 2011. “The Telomeric Cdc13 Protein Interacts Directly With the Telomerase Subunit Est1 to Bring It to Telomeric DNA Ends in Vitro.”. Proc Natl Acad Sci U S A 108 (51): 20362-9. doi:10.1073/pnas.1100281108.

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Bochman, Matthew, Colleen Judge, and Virginia Zakian. (2011) 2011. “The Pif1 Family in Prokaryotes: What Are Our Helicases Doing in Your Bacteria?”. Mol Biol Cell 22 (12): 1955-9. doi:10.1091/mbc.E11-01-0045.

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Paeschke, Katrin, John Capra, and Virginia Zakian. (2011) 2011. “DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces Cerevisiae Pif1 DNA Helicase.”. Cell 145 (5): 678-91. doi:10.1016/j.cell.2011.04.015.

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Tuzon, Creighton, Yun Wu, Angela Chan, and Virginia Zakian. (2011) 2011. “The Saccharomyces Cerevisiae Telomerase Subunit Est3 Binds Telomeres in a Cell Cycle- and Est1-Dependent Manner and Interacts Directly With Est1 in Vitro.”. PLoS Genet 7 (5): e1002060. doi:10.1371/journal.pgen.1002060.

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McGee, Jean, Jane Phillips, Angela Chan, Michelle Sabourin, Katrin Paeschke, and Virginia Zakian. (2010) 2010. “Reduced Rif2 and Lack of Mec1 Target Short Telomeres for Elongation Rather Than Double-Strand Break Repair.”. Nat Struct Mol Biol 17 (12): 1438-45. doi:10.1038/nsmb.1947.

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Fachinetti, Daniele, Rodrigo Bermejo, Andrea Cocito, Simone Minardi, Yuki Katou, Yutaka Kanoh, Katsuhiko Shirahige, Anna Azvolinsky, Virginia Zakian, and Marco Foiani. (2010) 2010. “Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements.”. Mol Cell 39 (4): 595-605. doi:10.1016/j.molcel.2010.07.024.

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Sabouri, Nasim, Karin McDonald, Christopher Webb, Ileana Cristea, and Virginia Zakian. (2012) 2012. “DNA Replication through Hard-to-Replicate Sites, Including Both Highly Transcribed RNA Pol II and Pol III Genes, Requires the S. Pombe Pfh1 Helicase.”. Genes Dev 26 (6): 581-93. doi:10.1101/gad.184697.111.

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Zakian, Virginia. (2012) 2012. “Telomeres: The Beginnings and Ends of Eukaryotic Chromosomes.”. Exp Cell Res 318 (12): 1456-60. doi:10.1016/j.yexcr.2012.02.015.

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Chisholm, Karen, Sarah Aubert, Krister Freese, Virginia Zakian, Mary-Claire King, and Piri Welcsh. 2012. “A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1.”. PLoS One 7 (2): e30748. doi:10.1371/journal.pone.0030748.

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Sabouri, Nasim, John Capra, and Virginia Zakian. (2014) 2014. “The Essential Schizosaccharomyces Pombe Pfh1 DNA Helicase Promotes Fork Movement past G-Quadruplex Motifs to Prevent DNA Damage.”. BMC Biol 12: 101. doi:10.1186/s12915-014-0101-5.

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