DNA Helicases

Schulz, and Zakian. (1994) 1994. “The Saccharomyces PIF1 DNA Helicase Inhibits Telomere Elongation and De Novo Telomere Formation.”. Cell 76 (1): 145-55.

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Bessler, Torres, and Zakian. (2001) 2001. “The Pif1p Subfamily of Helicases: Region-Specific DNA Helicases?”. Trends Cell Biol 11 (2): 60-5.

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Zhou, Monson, Teng, Schulz, and Zakian. (2000) 2000. “Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast.”. Science 289 (5480): 771-4.

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Ivessa, Zhou, and Zakian. (2000) 2000. “The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA.”. Cell 100 (4): 479-89.

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Tham, and Zakian. (2000) 2000. “Telomeric Tethers.”. Nature 403 (6765): 34-5. doi:10.1038/47385.

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Callahan, Julie, Kenneth Andrews, Virginia Zakian, and Catherine Freudenreich. (2003) 2003. “Mutations in Yeast Replication Proteins That Increase CAG CTG Expansions Also Increase Repeat Fragility.”. Mol Cell Biol 23 (21): 7849-60.

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Zhou, Jin-Qiu, Haiyan Qi, Vincent Schulz, Maria Mateyak, Ellen Monson, and Virginia Zakian. (2002) 2002. “Schizosaccharomyces Pombe pfh1+ Encodes an Essential 5’ to 3’ DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases.”. Mol Biol Cell 13 (6): 2180-91.

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Ivessa, Andreas, Jin-Qiu Zhou, Vince Schulz, Ellen Monson, and Virginia Zakian. (2002) 2002. “Saccharomyces Rrm3p, a 5’ to 3’ DNA Helicase That Promotes Replication Fork Progression through Telomeric and Subtelomeric DNA.”. Genes Dev 16 (11): 1383-96. doi:10.1101/gad.982902.

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Mangahas, Alexander, Sandell, and Zakian. (2001) 2001. “Repair of Chromosome Ends After Telomere Loss in Saccharomyces.”. Mol Biol Cell 12 (12): 4078-89.

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Ivessa, Andreas, Brian Lenzmeier, Jessica Bessler, Lara Goudsouzian, Sandra Schnakenberg, and Virginia Zakian. (2003) 2003. “The Saccharomyces Cerevisiae Helicase Rrm3p Facilitates Replication past Nonhistone Protein-DNA Complexes.”. Mol Cell 12 (6): 1525-36.

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Azvolinsky, Anna, Stephen Dunaway, Jorge Torres, Jessica Bessler, and Virginia Zakian. (2006) 2006. “The S. Cerevisiae Rrm3p DNA Helicase Moves With the Replication Fork and Affects Replication of All Yeast Chromosomes.”. Genes Dev 20 (22): 3104-16. doi:10.1101/gad.1478906.

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Boulé, Jean-Baptiste, and Virginia Zakian. 2006. “Roles of Pif1-Like Helicases in the Maintenance of Genomic Stability.”. Nucleic Acids Res 34 (15): 4147-53. doi:10.1093/nar/gkl561.

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Boulé, Jean-Baptiste, Leticia Vega, and Virginia Zakian. (2005) 2005. “The Yeast Pif1p Helicase Removes Telomerase from Telomeric DNA.”. Nature 438 (7064): 57-61. doi:10.1038/nature04091.

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Fisher, Timothy, and Virginia Zakian. (2005) 2005. “Ku: A Multifunctional Protein Involved in Telomere Maintenance.”. DNA Repair (Amst) 4 (11): 1215-26. doi:10.1016/j.dnarep.2005.04.021.

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Bessler, Jessica, and Virginia Zakian. (2004) 2004. “The Amino Terminus of the Saccharomyces Cerevisiae DNA Helicase Rrm3p Modulates Protein Function Altering Replication and Checkpoint Activity.”. Genetics 168 (3): 1205-18. doi:10.1534/genetics.104.028035.

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Torres, Jorge, Sandra Schnakenberg, and Virginia Zakian. (2004) 2004. “Saccharomyces Cerevisiae Rrm3p DNA Helicase Promotes Genome Integrity by Preventing Replication Fork Stalling: Viability of Rrm3 Cells Requires the Intra-S-Phase Checkpoint and Fork Restart Activities.”. Mol Cell Biol 24 (8): 3198-212.

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Torres, Jorge, Jessica Bessler, and Virginia Zakian. (2004) 2004. “Local Chromatin Structure at the Ribosomal DNA Causes Replication Fork Pausing and Genome Instability in the Absence of the S. Cerevisiae DNA Helicase Rrm3p.”. Genes Dev 18 (5): 498-503. doi:10.1101/gad.1154704.

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Boulé, Jean-Baptiste, and Virginia Zakian. 2007. “The Yeast Pif1p DNA Helicase Preferentially Unwinds RNA DNA Substrates.”. Nucleic Acids Res 35 (17): 5809-18. doi:10.1093/nar/gkm613.

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Vega, Leticia, Jane Phillips, Brian Thornton, Jennifer Benanti, Mutiat Onigbanjo, David Toczyski, and Virginia Zakian. (2007) 2007. “Sensitivity of Yeast Strains With Long G-Tails to Levels of Telomere-Bound Telomerase.”. PLoS Genet 3 (6): e105. doi:10.1371/journal.pgen.0030105.

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Mateyak, Maria, and Virginia Zakian. (2006) 2006. “Human PIF Helicase Is Cell Cycle Regulated and Associates With Telomerase.”. Cell Cycle 5 (23): 2796-804. doi:10.4161/cc.5.23.3524.

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Paeschke, Katrin, Karin McDonald, and Virginia Zakian. (2010) 2010. “Telomeres: Structures in Need of Unwinding.”. FEBS Lett 584 (17): 3760-72. doi:10.1016/j.febslet.2010.07.007.

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Boulé, Jean-Baptiste, and Virginia Zakian. 2010. “Characterization of the Helicase Activity and Anti-Telomerase Properties of Yeast Pif1p in Vitro.”. Methods Mol Biol 587: 359-76. doi:10.1007/978-1-60327-355-8_25.

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Bochman, Matthew, Nasim Sabouri, and Virginia Zakian. (2010) 2010. “Unwinding the Functions of the Pif1 Family Helicases.”. DNA Repair (Amst) 9 (3): 237-49. doi:10.1016/j.dnarep.2010.01.008.

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Azvolinsky, Anna, Paul Giresi, Jason Lieb, and Virginia Zakian. (2009) 2009. “Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces Cerevisiae.”. Mol Cell 34 (6): 722-34. doi:10.1016/j.molcel.2009.05.022.

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Ribeyre, Cyril, Judith Lopes, Jean-Baptiste Boulé, Aurèle Piazza, Aurore Guédin, Virginia Zakian, Jean-Louis Mergny, and Alain Nicolas. (2009) 2009. “The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences in Vivo.”. PLoS Genet 5 (5): e1000475. doi:10.1371/journal.pgen.1000475.

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Pinter, Stefan, Sarah Aubert, and Virginia Zakian. (2008) 2008. “The Schizosaccharomyces Pombe Pfh1p DNA Helicase Is Essential for the Maintenance of Nuclear and Mitochondrial DNA.”. Mol Cell Biol 28 (21): 6594-608. doi:10.1128/MCB.00191-08.

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Sabouri, Nasim, Karin McDonald, Christopher Webb, Ileana Cristea, and Virginia Zakian. (2012) 2012. “DNA Replication through Hard-to-Replicate Sites, Including Both Highly Transcribed RNA Pol II and Pol III Genes, Requires the S. Pombe Pfh1 Helicase.”. Genes Dev 26 (6): 581-93. doi:10.1101/gad.184697.111.

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Chisholm, Karen, Sarah Aubert, Krister Freese, Virginia Zakian, Mary-Claire King, and Piri Welcsh. 2012. “A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1.”. PLoS One 7 (2): e30748. doi:10.1371/journal.pone.0030748.

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Bochman, Matthew, Colleen Judge, and Virginia Zakian. (2011) 2011. “The Pif1 Family in Prokaryotes: What Are Our Helicases Doing in Your Bacteria?”. Mol Biol Cell 22 (12): 1955-9. doi:10.1091/mbc.E11-01-0045.

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Paeschke, Katrin, John Capra, and Virginia Zakian. (2011) 2011. “DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces Cerevisiae Pif1 DNA Helicase.”. Cell 145 (5): 678-91. doi:10.1016/j.cell.2011.04.015.

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Fachinetti, Daniele, Rodrigo Bermejo, Andrea Cocito, Simone Minardi, Yuki Katou, Yutaka Kanoh, Katsuhiko Shirahige, Anna Azvolinsky, Virginia Zakian, and Marco Foiani. (2010) 2010. “Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements.”. Mol Cell 39 (4): 595-605. doi:10.1016/j.molcel.2010.07.024.

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Sabouri, Nasim, John Capra, and Virginia Zakian. (2014) 2014. “The Essential Schizosaccharomyces Pombe Pfh1 DNA Helicase Promotes Fork Movement past G-Quadruplex Motifs to Prevent DNA Damage.”. BMC Biol 12: 101. doi:10.1186/s12915-014-0101-5.

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McDonald, Karin, Nasim Sabouri, Christopher Webb, and Virginia Zakian. (2014) 2014. “The Pif1 Family Helicase Pfh1 Facilitates Telomere Replication and Has an RPA-Dependent Role During Telomere Lengthening.”. DNA Repair (Amst) 24: 80-6. doi:10.1016/j.dnarep.2014.09.008.

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Zhou, Ruobo, Jichuan Zhang, Matthew Bochman, Virginia Zakian, and Taekjip Ha. (2014) 2014. “Periodic DNA Patrolling Underlies Diverse Functions of Pif1 on R-Loops and G-Rich DNA.”. Elife 3: e02190. doi:10.7554/eLife.02190.

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Webb, Christopher, Yun Wu, and Virginia Zakian. (2013) 2013. “DNA Repair at Telomeres: Keeping the Ends Intact.”. Cold Spring Harb Perspect Biol 5 (6). doi:10.1101/cshperspect.a012666.

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Paeschke, Katrin, Matthew Bochman, Daniela Garcia, Petr Cejka, Katherine Friedman, Stephen Kowalczykowski, and Virginia Zakian. (2013) 2013. “Pif1 Family Helicases Suppress Genome Instability at G-Quadruplex Motifs.”. Nature 497 (7450): 458-62. doi:10.1038/nature12149.

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McDonald, Karin, Amanda Guise, Parham Pourbozorgi-Langroudi, Ileana Cristea, Virginia Zakian, John Capra, and Nasim Sabouri. (2016) 2016. “Pfh1 Is an Accessory Replicative Helicase That Interacts With the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.”. PLoS Genet 12 (9): e1006238. doi:10.1371/journal.pgen.1006238.

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Geronimo, Carly, and Virginia Zakian. (2016) 2016. “Getting It Done at the Ends: Pif1 Family DNA Helicases and Telomeres.”. DNA Repair (Amst) 44: 151-8. doi:10.1016/j.dnarep.2016.05.021.

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Stundon, Jennifer, and Virginia Zakian. (2015) 2015. “Identification of Saccharomyces Cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells With Reduced Levels of the Nuclear Pif1 DNA Helicase.”. G3 (Bethesda) 5 (12): 2913-8. doi:10.1534/g3.115.021139.

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Phillips, Jane, Angela Chan, Katrin Paeschke, and Virginia Zakian. (2015) 2015. “The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres.”. PLoS Genet 11 (4): e1005186. doi:10.1371/journal.pgen.1005186.

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